A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons.

نویسندگان

  • Yu-Man Ho
  • Ngan-Pan Bennett Au
  • Ka-Leung Wong
  • Chris Tsz-Leung Chan
  • Wai-Ming Kwok
  • Ga-Lai Law
  • Kwong-Kit Tang
  • Wai-Yeung Wong
  • Chi-Him Eddie Ma
  • Michael Hon-Wah Lam
چکیده

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}(2+) (1) and {[Pt(L2)]2(μ-dppm)}(2+) (2), as lysosome-specific two-photon imaging probes.

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عنوان ژورنال:
  • Chemical communications

دوره 50 32  شماره 

صفحات  -

تاریخ انتشار 2014